Police and an air ambulance were called to a serious two-vehicle crash on the A1079 near Market Weighton yesterday.
The collision happened at about 3.48pm and involved a red Mitsubishi Colt and a white Citroen Berlingo van.
One of the people in the vehicles sustained serious but non-life threatening injuries and was taken to Hull Royal Infirmary by air ambulance.
Officers assisted with a full road closure to enable the air ambulance to land.
The road had to be closed of at Cliff Road and the junction of York Road.
The condition of the casualty is not known at this stage.
Anyone with information is asked to call 101 regarding log number 409 of Tuesday 25 February.